A collaborative approach to amyloidosis and a multidisciplinary care framework - position statement from the International Society of Amyloidosis
Change of guard at - a tribute to outgoing Editor in Chief, Professor Per Westermark
Commentary to revisiting the genetic epidemiology of ATTRv in Spain: the Balearic Islands as a high-prevalence founder focus
Single-slide detection and typing of AL renal amyloidosis: combining mass spectrometry imaging and digital pathology
Amyloid typing, particularly in monoclonal gammopathies of renal significance, can be technically challenging. Matrix-Assisted Laser Desorption/Ionisation-Mass Spectrometry Imaging (MALDI-MSI) has been proposed as a non-destructive method to detect and type amyloid deposits on a single tissue slide. This study aims to confirm this capability of MALDI-MSI in renal light chain amyloidosis (AL amyloidosis), irrespective of the fixative utilised, confronting results with other traditional and upcoming methods for amyloid detection.
Revisiting the genetic epidemiology of ATTRv in Spain: the Balearic Islands as a high-prevalence founder focus
Frontline Dara-CyBorD for AL amyloidosis: high response rates and cytogenetic insights from a real-world cohort
An Accelerated Sonication-Assisted Preparation method for mass spectrometry-based identification of subtype specific amyloidogenic proteins in fat aspirates
Cardiac Phenotype and Clinical Outcomes in Randall Disease versus Light-Chain Amyloidosis
AA amyloidosis as an adverse event of immune checkpoint inhibitor therapy: evidence from the FDA adverse event reporting system and a systematic review
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are linked to immune-related adverse events (irAEs). Secondary (AA) amyloidosis, an inflammatory complication involving serum amyloid A deposition, has been sporadically reported in ICI-treated patients. We investigated the link between ICI therapy and AA amyloidosis using pharmacovigilance data and a systematic review.
Optimized methods for efficient application of immunogold electron microscopy to amyloid fibrils typing
Amyloidosis is a group of disorders characterized by aggregation of abnormal amyloid protein in various tissues, often leading to organ dysfunction and failure. We optimized the immunogold electron microscopy (IEM) technique to enable efficient amyloid typing in 4% paraformaldehyde-fixed (PFA) and formalin-fixed paraffin-embedded (FFPE) tissues.
Limited diagnostic utility of systematic Congo red staining in bone marrow biopsies
Clinical profile and outcome of AA amyloidosis associated kidney disease in India
AA amyloidosis is a rare but significant cause of chronic kidney disease (CKD). We aimed to characterize the clinical profile of patients with AA amyloidosis affecting the kidneys in the Indian subcontinent.
Failure to screen for monoclonal proteins in patients who undergo bone scintigraphy for suspected cardiac amyloidosis
A comparison of single versus combination mechanism treatment for transthyretin amyloid cardiomyopathy
Tafamidis treatment and neuropsychiatric dysfunction in patients with cardiac aTTR: a post-hoc analysis of the ATTRACT trial
Neuropathy impairment and nutritional status with eplontersen in patients with hereditary transthyretin-mediated amyloidosis
Cold pressor test and paradoxical blood pressure reduction in light chain amyloidosis
Patients with AL amyloidosis present sustained paradoxical vasodilation in response to sympathetic stimulation by cold pressor test (CPT). The clinical relevance is unknown.
Bile cast nephropathy presenting as acute kidney injury in systemic light chain amyloidosis with severe hepatic involvement
Amyloid myopathy in the internal oblique muscle of patients with wild-type transthyretin cardiac amyloidosis
