CLINICAL AND EXPERIMENTAL DERMATOLOGY

Comment on 'Emerging Threats in Dermatophytosis: Antimicrobial Resistance in Trichophyton, with Emphasis on T. indotineae': Insights from a case series of T. indotineae' seen in a regional health board in Scotland, UK
Farquhar K, McKenna L and Randhawa A
An additional dermoscopic clue in basal cell carcinoma of the lower limb: the purpura-like pattern
Spadafora M, Sticchi A, Navarrete-Dechent C, Kaleci S, Pellacani G and Longo C
Dermoscopy is a critical tool for diagnosing basal cell carcinoma (BCC) and differentiating its histopathological subtypes. However, BCC on the lower limbs may present with atypical dermoscopic features, making its diagnosis challenging.
Erythema Multiforme Major triggered by salvage radiotherapy for prostate adenocarcinoma
Passby L, Hejmadi R and Fremlin G
Delicate yet determined: living with severe recessive dystrophic epidermolysis bullosa
Sexton F and Gale J
Time to think about the ink: Why tattoo geography and regulation matter in clinical dermatology
Nolan B, Quigley C and Roche D
Emerging Epidemiological Trends in Primary Cutaneous Lymphomas: A Population-Based Analysis
Lu Y, Zhang L and Ying X
Primary cutaneous lymphomas (CLs), comprising cutaneous T-cell lymphomas (CTCLs) and cutaneous B-cell lymphomas (CBCLs), are rare non-Hodgkin lymphomas with distinct epidemiological characteristics. How the incidence rates of CLs changed over the past decade has not been well documented.
Recurrent Blisters on the Hands and Feet in an Elderly Man
Cheng TT and Chu CH
Clinical Tumour Size Reduction with Intralesional Methotrexate in Facial Cutaneous Squamous Cell Carcinoma
Escalante L, Borja Chaves A, Maldonado A and Mallipeddi R
Recurrent ulceration in a female with systemic sclerosis
Xu M, Cai S and Cao Y
Janus kinase inhibitors in severe alopecia areata: balancing patient expectations with clinician safety considerations
Jackson EK and Patel NP
Frailty in Hidradenitis Suppurativa: a case-control study
Howard-James C, Murray G, Al Hosni F, Maguire M, Lai F, Yoo H, Quigley C, Yong JF, Ralph J, Hollywood A, Dalton C, Howard-James N and Tobin AM
An elderly patient with multilocular epitheloid sarcoma mimicking prurigo nodularis
Gambichler T, Katenkamp K, Noldes K, Kautz O and Boms S
General Dermatology and dermatology in primary care
Dickson D, Lim PN and MacDonald A
Acute Ulceration of the scalp in an elderly patient
Fairhurst O and Anderson A
Hypereosinophilic dermatitis misdiagnosed as chronic eczema in an elderly male with multiple comorbidities
Yao H, Wu Y, Li J and Zhang R
Efficacy and response of the use of biologic and small-molecule combination therapy in adults with atopic dermatitis
Silva I, Miriyala S and Khattri S
From Flat to Firm: A Congenital Plaque That Thickens on Stimulation
Odyakmaz Demirsoy E, Adak M and Eruyar AT
A novel missense mutation responsible for a unique erythrokeratodermia variabilis patient with skin lesions in a swirling pattern
Hua S, Fang B, Liu Y, Hu Z, Zhang J and Xue Z
Erythrokeratodermia variabilis (EKV) is a rare, inherited skin disease characterized by migratory erythematous areas and fixed hyperkeratosis plaques, which is most commonly caused by mutations in the GJB3, GJB4 or GJA1 gene. This study reports a 5-month-old male infant presenting with erythematous skin lesions on the trunk and brown hyperkeratotic plaques with a unique swirling pattern on the extremities. Whole exome sequencing (WES) revealed a heterozygous missense mutation c.134G>C in the GJB3 gene, which has not been reported before. The PROVEAN analysis revealed a PROVEAN score of -3.065, which was below the threshold of -2.5, moreover, the 3-D structure predicted missense mutation p.Gly45Ala could compromise the three-dimensional stability of the GJB3 protein, suggesting a deleterious effect. In Conclusion, we report a novel missense mutation (p. Gly45Ala) in the GJB3 gene that caused EKV accompanying with a unique swirling pattern in a Chinese family, which broadens the genetic and phenotypic spectrum of EKV.
Does ciclosporin cause symptomatic hypomagnesaemia in psoriasis patients included in the British Association of Dermatologists Biologics and Immunomodulators Registry (BADBIR) pharmacovigilance registry?
Clarke E, van Bodegraven B and Shipman AR
Online Survey Research in Dermatology: Are Your Participants Who You Think They Are?
King Stokes N, McCusker S, Daly A, Hunjan M, Lowe A, Charman C, Solman L, George S and Burden-Teh E
Surveys are a commonly used research method in dermatology. The use of online surveys has increased over the last decade, as has the use of social media to recruit potential participants. There is a growing risk of fraudulent or bot responses to online surveys which threatens data integrity and wastes researcher time and funding. We report our experience of conducting an online survey investigating the experiences of adolescents and parents having teleconsultations for paediatric eczema. We experienced a rapid influx of responses within 24 hours, of which 95.7% appeared fraudulent. Indicators of fraudulent responses included duplicate free-text responses and clusters of surveys that were started and completed in tandem. Dermatological researchers should be aware of this issue and incorporate a plan to prevent, identify and manage fraudulent responses into the study protocol.
Peer-learning in procedural training in dermatology - an exploratory study on medical student's learning experiences
Ivert P, Bradley M and Brauner H
This project aimed to investigate medical students' experiences of peer-learning in procedural training in dermatology with a mixed methods approach. Fifteen students participated in peer-learning and were taught half of the procedures by a teacher in smaller groups and thereafter taught their peers. The effect of the peer-learning was evaluated by questionnaires and semi structured group interviews. The students reported good exchange of knowledge with their peer and that it was more rewarding to do the activity together with a peer. Peer-learning was also believed to increase focus on activity, repetition and concentration. The security in the group and the presence and support from the teacher was reported to be important. In conclusion, this exploratory project proves the feasibility of implementing peer-learning during the procedural training in dermatology for medical students and finds self-reported benefits including good exchange of knowledge with peer and increased focus on the activity.