To develop ionically cross-linked pH-responsive interpenetrating polysaccharide network hydrogel tablets for the colon-targeted delivery of budesonide (BUD).

Empagliflozin a sodium-glucose co-transporter 2 inhibitor, and Metoprolol succinate, a cardioselective β1-blocker, are co-formulated in a novel bilayer tablet currently under clinical evaluation. Reliable stability-indicating methods are required for simultaneous quantification of these drugs and to ensure environmental sustainability of pharmaceutical analysis.

Bacterial infections caused by multidrug-resistant (MDR) strains pose a serious global health threat. This study aimed to evaluate the antibacterial efficacy of green-synthesized copper nanoparticles (G-CuNPs) against MDR strains of , , spp., and .

To enhance the dermal delivery and therapeutic potential of psoralen from in psoriasis through phytosomal encapsulation.

Lyophilization is the preferred method to stabilize labile protein formulations in order to attain longer shelf life. Thus, the understanding of different parameters of lyophilization along with inherent properties of plasma protein formulations is very essential to achieve improved stability.

Valrubicin (VAL) is an N-trifluoroacetyl 14-valerate derivative of the anthracycline doxorubicin (DOX)and is known to have anti-tumor activity. Unfortunately, itis characterized by low solubility and instability in aqueous solutions, which hampers its applications and reduces its therapeutic efficacy.

This study presents a sustainable extraction process for obtaining plant active substances (PAS) from the leaves of Spenn. (rosemary) and semi-solid microemulsions (SSME) at the same time. The extraction method uses a sustainable solvent system of surfactants, co-surfactants, and water, yielding high PAS miscibility.

Simvastatin, a lipid-lowering drug, has low oral bioavailability due to poor solubility and extensive first-pass metabolism. Transdermal delivery may overcome these limitations.

Etodolac (ETD), an insoluble anti-inflammatory drug, undergoes first-pass metabolism, which limits its oral bioavailability. The current study presents the trials for improvement of drug solubility on one hand and formulation of different emulgel systems loaded with modified drug on the other hand.

The Saudi market offers dosages of metformin that have varying release rates and can lead to different pharmacological reactions. Studying formulation bioequivalences helps patients choose the optimum medicine without affecting pharmacological responses.

Formulation research benefits from high-throughput excipient screening methods, considering the ever-growing excipient space. We investigate the use of 384-well plates as freeze-drying containers and for subsequent analyses, to screen the effect of excipients on the stability of proteins during freeze-drying. For both the preparation and analysis methods of a range of β-galactosidase formulations, an 8-tip pipetting robot was used. Formulations were lyophilized in 384-well plates, which were also used for subsequent enzymatic activity assessment, serving as an indication of protein stability. Excipient screening revealed that threonine, histidine, arginine, sucrose, and trehalose enhance the recovery of the enzymatic activity of β-galactosidase compared to the protein freeze-dried in buffer without other excipients. Moreover, pullulan only showed a stabilizing effect when it was combined with low-molecular-weight excipients that by themselves were poor stabilizers, which was especially the case for serine and to some extent for valine. There were no significant differences in enzymatic activity when comparing the automated 384-well plate freeze-drying method with a common in-vial method, while offering the added sustainability benefits of increased throughput, reduced workload, and lower protein and reagent usage. This approach might be suitable for the pre-selection of viable formulations.

Tacrolimus is a potent macrolide immunosuppressant widely utilized in solid organ transplantation and the management of autoimmune disorders. The current study aimed to investigate the compatibility of tacrolimus with four commonly used excipients, including sodium croscarmellose, hydroxypropyl methylcellulose (HPMC), magnesium stearate, and lactose monohydrate.

To enhance the aqueous solubility and dissolution rate of cilnidipine (CLN), a BCS Class II antihypertensive drug with poor oral bioavailability (13%), by developing oral nanocrystals (NCs) using a scalable antisolvent precipitation and high-speed homogenization technique.

This study aimed to develop and evaluate ginsenoside Rg3 (GRg3)-loaded alginate/poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as an oral drug delivery system with improved anticancer and antioxidant potential.

Metformin is gold standard for polycystic ovary syndrome (PCOS), but associated with gastrointestinal side effects, leading to poor patient adherence. Present oral fast-dissolving films (OFDFs) offer rapid disintegration, improving drug delivery, therapeutic outcomes, and patient compliance.

Oridonin (ORI) is an ent-kaurene tetracyclic diterpenoid with anti-tumor activities in various tumor cell lines. However, its hydrophobicity and non-targeting have greatly limited the clinical application of ORI. In the present study, long-circulating liposomes loading ORI and targeting lung cancer cells were established to solve these problems.

This study aimed to compare the dissolution kinetics of sustained-release bolus tablets formulated with different pharmaceutical binders using two systems-the continuous-flow artificial saliva rig and the Ankom Daisy II incubator-to evaluate how the experimental setup influences the interpretation of release behavior and kinetic modeling.

This review article outlines the transformative impact of Artificial Intelligence (AI) in the pharmaceutical sciences, focusing on its integration with modern technologies and its role in advancing medication research, development, production, and digital transformation.

To elucidate the application potential of ferritin nanocarriers in targeted cancer therapy, particularly for central nervous system (CNS) tumors (e.g. glioblastoma), focusing on their structural advantages, drug-loading capacity, targeting strategies, and emerging therapeutic directions.