Dalbavancin's pharmacokinetic parameters suggest obesity may affect serum and tissue concentrations, but currently there is no outcome data in the obese population with invasive infections.

The objective of this review is to evaluate clinical data regarding use of toripalimab and penpulimab use in recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) and to assess their impact on patient care.

To review the pharmacology, efficacy, and safety profile of crinecerfont as adjunctive therapy in treating classic congenital adrenal hyperplasia (CAH).

Therapeutic intensity unfractionated heparin (UFH) infusions require titration to target a therapeutic activated partial thromboplastin time (aPTT) or UFH anti-Xa. At The Johns Hopkins Hospital (JHH) and Johns Hopkins Bayview Medical Center (JHBMC), a computerized nurse-managed UFH calculator was built into the electronic health record (EHR) to improve adherence to institutional nomograms.

Remdesivir has demonstrated effect in reducing COVID-19 mortality and disease progression, while conflicting associations have been reported between remdesivir and renal outcomes.

Dapsone is an alternative prophylactic agent for opportunistic infection in kidney transplant recipients (KTRs) with sufficient glucose-6-phosphate dehydrogenase levels. Potential disadvantages include increased risk for anemia and urinary tract infection (UTI) with dapsone.

To review the pharmacology, usage, efficacy, and safety of fenfluramine in treating seizures in pediatric patients with Lennox-Gastaut syndrome or Dravet syndrome.

To assess the efficacy and safety of pitolisant, a selective histamine H₃ receptor antagonist/inverse agonist, for excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).

To our knowledge, there are no data assessing sedation requirements in patients on buprenorphine/naloxone (Bup/Nx) prior to admission (PTA).

Dual antiplatelet therapy (DAPT) is essential after percutaneous coronary intervention (PCI) but increases gastrointestinal (GI) bleeding risk, necessitating acid suppressants. The cardiovascular safety of concomitant proton pump inhibitor (PPI) use with clopidogrel has been debated due to potential drug-drug interactions, although recent evidence suggests that these concerns may be less clinically significant.

To describe the properties of a newly approved intranasal powder formulation of dihydroergotamine (DHE) for the acute treatment of migraine headaches.

Critically ill patients receiving continuous renal replacement therapy (CRRT) commonly experience hypotension necessitating fluids, ultrafiltration (UF) adjustment, or vasopressors. There is limited evidence evaluating 25% albumin on vasopressor requirements in this population.

To evaluate the pharmacology, efficacy, safety, and clinical use of datopotamab deruxtecan (Dato-DXd), a recently approved trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC), in the treatment of advanced solid tumors.

Neuromuscular blocking agents (NMBAs) are suggested as an option in moderate to severe acute respiratory distress syndrome (ARDS) to improve ventilator synchrony (VS) and overall oxygenation. However, NMBA titration strategies have not been adequately compared.

Heart failure with reduced ejection fraction carries high morbidity and mortality. Guideline-directed medical therapy (GDMT) improves outcomes, yet real-world use is often suboptimal. Multiple scoring tools quantifying GDMT optimization have been developed to identify areas of improvement, including GDMT count, Optimal Medical Therapy (OMT), modified OMT (mOMT), and Kansas City Medical Optimization (KCMO) scores. Their clinical utility in predicting readmissions is uncertain.

The guidelines recommend intravenous (IV) iron for patients with heart failure (HF) with a reduced or mildly reduced ejection fraction. IV iron is often administered during hospitalization. However, care transitions from inpatient to outpatient settings for IV iron are suboptimal, and only about one-third of patients receive follow-up iron study measurements to assess the need for IV iron at outpatient settings after inpatient IV iron. Limited data is available to improve the current practice of IV iron during care transitions.

Previous retrospective studies involving mixed intensive care unit (ICU) populations found antipsychotic continuation rates ranging from 21% to 61% at hospital discharge. Surgical ICU admission was cited as a risk factor for antipsychotic continuation, although data in the trauma population are limited.