Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. Meanwhile, the development of MASLD is related to dysbiosis of the gut microbiota (GM). Our previous studies have shown that Vitamin K2 (VK2) has considerable potential to ameliorate mitochondrial dysfunction in mice fed a high-fat diet (HFD); however, the mechanism through which VK2 improves mitochondrial function and mitigates MASLD remains unclear.

Prolonged or intense exercise can disrupt gastrointestinal (GI) function and gut microbiota, impairing athletic performance. Dietary fibre supplementation may enhance gut microbiota diversity, improve body composition, and promote recovery in athletes. This study aimed to explore the effects of dietary fibre supplementation at two doses for 8 weeks on these aspects in college basketball players.

Polycystic ovary syndrome (PCOS) is a leading endocrine disorder in reproductive-aged women. While dietary interventions are widely advocated, the distinct roles of adiposity and dietary inflammation in driving PCOS phenotypes remain unclear. Therefore, this study aimed to dissect the contributions of body mass index (BMI) and dietary inflammatory index (DII) to hyperandrogenism and insulin resistance (IR) in PCOS.

Calcium plays a central role in gastrointestinal (GI) physiology through regulating smooth muscle contractility, acid secretion, epithelial barrier integrity, and immune signaling. The dysregulation of calcium homeostasis has been increasingly implicated in the pathogenesis of GI disorders, including colorectal cancer, inflammatory bowel disease, peptic ulcer, and pancreatitis. Specifically, aberrant calcium-sensing receptor (CaSR) signaling has emerged as a critical molecular mechanism in colorectal tumorigenesis; meanwhile, calcium-mediated pathways influence gastric acid production and intestinal motility. This review critically evaluated recent advances in calcium signaling within the GI tract, highlighting the crosstalk involved with the gut microbiota and the roles of downstream effectors, including transient receptor potential vanilloid type 6 and store-operated calcium entry. This review also examined the therapeutic implications of calcium supplementation across various GI conditions, including bioavailability challenges under different disease states and nutrient interactions involving vitamin D and phosphate. Our review further addresses the role of calcium in mucosal immunity, the clinical relevance of hypocalcemia in GI diseases, and the potential of microbiome-guided nutritional interventions. However, despite growing mechanistic insights, considerable gaps remain in understanding host-microbiota-calcium interactions, genotype-specific responses to calcium, and long-term clinical outcomes. Thus, future research should clarify the dose-response relationships, stratify patient populations by CaSR polymorphisms and microbiome profiles, and establish precision strategies for calcium-based interventions in digestive health.

Selenium, a trace element with antioxidant properties, plays a vital role in the metabolism of microorganisms. Meanwhile, supplementation with selenium may also modify the activity of probiotics. Thus, this study aimed to analyze the effect of selenium supplementation on the growth, tolerance, and selenium binding capacity of two probiotic strains: DSM24730 and 299v. In particular, this study aimed to determine whether introducing this microelement into the culture environment would affect the growth capacity and detoxification mechanisms of these bacteria. Additionally, the ability of the selected strains to absorb and store selenium was analyzed, which could have potential benefits for both human health and the quality of probiotic preparations.

Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in both pediatric and adult patients with ulcerative colitis (UC). The association between serum vitamin A levels and serum RBP4 levels, as well as the underlying mechanism involved inimpaired vitamin A transport during inflammation in UC patients, has yet to been investigated.

Dietary interventions have exhibited promise in restoring microbial balance in chronic kidney disease. A low-protein calorie-restricted diet can reduce kidney injury in diabetic rodents. However, whether the renoprotective effects of this dietary intervention in murine diabetic kidney disease models are linked to gut microbiota modulation remains to be determined.

The vitamin B complex, a group of water-soluble vitamins, is essential for various metabolic and cellular processes and critical for achieving optimal surgical outcomes in plastic and cosmetic procedures. This review examines the mechanistic contributions of this complex at the cellular level, including any roles in mitochondrial bioenergetics, redox balance, gene regulation, and cellular repair mechanisms. Niacinamide, as a precursor to NAD⁺, enhances mitochondrial efficiency and facilitates energy production, supporting tissue regeneration. Pyridoxine functions as a cofactor in neurotransmitter biosynthesis and amino acid metabolism, contributing to nerve recovery post-surgery. Furthermore, cobalamin is crucial for maintaining the myelin sheath and facilitating axonal repair, thereby ensuring neuronal integrity and minimizing nerve damage. Additionally, pantothenic acid, through its role in coenzyme A synthesis, regulates fatty acid metabolism and accelerates cellular repair, aiding in wound healing. Biotin is fundamental for keratin synthesis and follicular cell proliferation, promoting skin integrity and hair regeneration, which are vital in aesthetic and reconstructive treatments. Meanwhile, thiamine ensures a sufficient energy supply for neuronal recovery and cellular resilience through modulating carbohydrate metabolism. Thus, by integrating these cellular mechanisms, the vitamin B complex enhances tissue repair, minimizes inflammation, and improves both aesthetic and functional outcomes. Advances in precision supplementation, innovative drug delivery methods, and regenerative medicine continue to expand the therapeutic potential of B vitamins in plastic and reconstructive surgery. This comprehensive overview underscores the clinical significance of these vitamins in optimizing surgical recovery and promoting long-term tissue health.

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and associated with severe complications, including cardiovascular diseases, neuropathy, nephropathy, and retinopathy. Although synthetic antidiabetic drugs are available, the side effects and limited long-term effectiveness of these medications highlight the urgent need for safer, more potent alternative therapies. L., a traditional medicinal plant rich in flavonoids, terpenoids, and bilobalide, has attracted attention for its potential role in diabetes management. This review critically evaluates the antidiabetic potential of by analyzing evidence from , , and clinical studies. Moreover, this review highlights the pharmacological actions of and its key bioactive compounds, focusing on their mechanisms of action, including the activation of adenosine monophosphate-activated protein kinase (AMPK), the translocation of glucose transporter type 4 (GLUT4), and the inhibition of protein tyrosine phosphatases. The review also discusses the therapeutic implications of supplementation and identifies gaps in clinical validation, optimal dosing, and safety profiling. Preclinical studies have demonstrated that improves glycemic control by enhancing glucose uptake, regulating insulin secretion, inhibiting α-glucosidase activity, and exerting antioxidant and anti-inflammatory effects. Additionally, clinical trials suggest that supplementation with can reduce oxidative stress, improve lipid profiles, and mitigate diabetes-related complications. However, despite these promising outcomes, inconsistencies remain in present study designs, dosages, and patient populations, which question the validity of results. Furthermore, studies related to the antidiabetic effect and underlying mechanisms of , such as modulation of AMPK pathways and GLUT4 expression, also remain inadequate and warrant further systematic investigation. may still be considered a complementary treatment approach in managing diabetes due to its broad pharmacological activities and favorable safety profile. However, well-designed, large-scale clinical trials are crucial for establishing standardized dosing regimens, confirming long-term safety, and fully elucidating the mechanisms of action. Integrating into therapeutic strategies could offer a natural, and effective adjunct for enhancing glycemic control and reducing diabetes-related complications.

The effects of dietary niacin on the risk of cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD) remain unclear.

Substantial experimental evidence has demonstrated that selenium, an essential micronutrient with pleiotropic physiological effects, also promotes dual antioxidant and anti-inflammatory effects. Meanwhile, the epidemiological association between dietary selenium consumption and mortality risk in diabetic kidney disease (DKD) remains underexplored. This investigation demonstrated a significant association between selenium intake and all-cause mortality among adult populations with DKD.

Obesity, a prevalent global health issue, is associated with testosterone deficiency (TD). A body shape index (ABSI) provides a more precise assessment of obesity and visceral fat, but its relationship with testosterone remains unclear. This study aimed to explore the association between ABSI and testosterone levels leading to TD.

This study aimed to determine whether administering intravenous vitamin C in patients with malignant neoplasm is associated with increased survival outcomes compared to no intravenous vitamin C administration.

Pressure injuries (PIs) are a significant issue for international healthcare systems. Particularly common among older adults with reduced mobility, PIs represent a considerable socio-healthcare burden, which deeply impacts the psychological well-being of patients. Malnutrition is one of the main risk factors for the development of PIs, as malnutrition hinders healing and increases the risk of complications. For these reasons, implementing appropriate nutritional interventions, often underestimated in clinical practice, is crucial to manage PIs effectively. This study primarily aimed to identify and synthesize the best scientific evidence on nutritional interventions to prevent, facilitate, or improve the healing of PIs in an adult population. Additionally, both qualitative and quantitative outcomes were analyzed.

Clinical and epidemiological evidence supports sodium reduction as an effective strategy to lower blood pressure and reduce the risk of stroke, cardiovascular disease, and overall mortality. High sodium (salt) intake is a well-established contributor to elevated blood pressure and adverse cardiovascular outcomes. The World Health Organization (WHO) recommends that adults should consume less than 5 g of table salt per day; however, the global average intake is estimated at around 10.78 g/day. The primary sources of dietary sodium vary by region: in high-income countries, the majority of salt intake comes from processed foods and meals prepared outside the home, while in many low-and middle-income countries, sodium is mainly added during home cooking or comes from condiments such as soy sauce and fish sauce. This review discusses the effects of high dietary sodium on blood pressure and vascular health, along with global consumption trends, regional disparities, and key nutritional sources. In addition to reducing sodium, adopting a salt-sensitive, whole-diet approach, such as increasing fruit and vegetable intake to boost potassium, can further protect cardiovascular health. Potassium-enriched, low-sodium salt substitutes are increasingly used in food production. Emerging strategies, including flavor enhancers, bitter blockers, spatial salt distribution, and microencapsulation, also help enhance saltiness perception while lowering sodium content. The review also summarizes national guidelines and those by the WHO, highlights selected country strategies, and calls for coordinated global and national efforts to reduce sodium intake and improve cardiovascular health worldwide.

Autism spectrum disorder (ASD) can be diagnosed as early as 18 months old, but more reliably after two years. Notably, no laboratory test exists to identify mothers at higher risk of having a child who will later be diagnosed with ASD or to identify at-risk infants before the manifestation of symptoms. One frequently described risk factor for neurodevelopmental disorders is vitamin B12 and folate deficiency, which results in macrocytic anemias.

Iron deficiency is a major global public health concern associated with various adverse outcomes.

Suboptimal hydration status has increasingly been recognized as a risk factor for the progression of chronic diseases. A nationwide survey conducted in China found that 82% of children aged 6 to 17 years failed to meet the recommended daily total water intake of 1600-2500 mL. On average, boys consumed 1603 ± 731 mL per day, while girls consumed 1487 ± 661 mL per day, placing them at a higher risk of dehydration. Worldwide studies have suggested associations between dehydration and chronic kidney disease, steatotic liver disease, and cardiovascular diseases in adults. However, there is a lack of evidence concerning hydration status and target organ damage in the pediatric population. Only a limited number of studies have suggested that suboptimal hydration status is associated with transient renal impairment, an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD), and decreased ventricular structure and function in children. This article reviews the association between hydration status and target organ damage in both adult and pediatric populations and summarizes tailored water intake recommendations for Chinese children. We aim to advance research on hydration status and kidney, liver, and cardiovascular health, especially in the pediatric population.

Probiotics are increasingly recognized for promoting beneficial effects on intestinal health. However, most probiotic strains have been insufficiently researched, underscoring the need for further studies to fully understand their potential health benefits, especially in metabolic conditions. Therefore, this study aimed to explore the role and possible mechanism of YDJ-03 (YDJ-03) and YDJ-6 (YDJ-6) in metabolic syndrome (MetS) and hyperuricemia.

Our study aimed to gain from a comprehensive understanding of organic food consumption in Switzerland.

Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However, given the inconclusive results from recent meta-analyses on L-carnitine, we conducted an umbrella meta-analysis of placebo-controlled and controlled trials to evaluate the effect of L-carnitine on anthropometric indices.