CANCER CAUSES & CONTROL

We don't want to boil the ocean: expanding cancer research in the era of climate change
Nogueira LM
COVID-19 impacts on the breast cancer care pathway among systemically marginalized communities in Ontario
Lofters AK, Premranjith P, Gayowksy A, Khalil I, Covelli AM and Daniel JM
Healthcare system pauses occurred worldwide due to COVID-19, and may have worsened pre-existing disparities in breast cancer care. In this population-based, retrospective cohort study, we investigated indicators of breast cancer care (i.e., adherence to screening guidelines, early vs. late-stage diagnosis, and mastectomy vs. breast-conserving surgery) before and after COVID-19 lockdowns in Ontario, with an emphasis on immigrant women.
The impact of social determinants of health on Black men at the point of prostate cancer diagnosis: a scoping review
Fullwood D, Fallon E, Asto-Flores E, Gordon V, Bolajoko OO, Jett H, Fudge M, Pressey S, Young ME, Ngufor C and Odedina F
Prostate cancer (CaP) disproportionately affects Black men, who face higher rates of late diagnosis and more aggressive disease. This study explores the social determinants of health and emotional support at the point of prostate cancer diagnosis (PPCD) and how these factors influence navigation, emotional responses, and healthcare behaviors among Black men.
The cancer divide: setting research priorities for understanding and addressing extreme rurality in cancer care delivery
Hoover RL, Mayer DK, Warner EL and Haines ER
Cancer care delivery research (CCDR) is increasingly acknowledging the critical role of geographic context; however, most definitions of rurality remain insufficiently granular. Grouping all non-urban areas into a single category mask the distinct barriers faced by individuals in remote and frontier regions. Patients living in these areas often navigate long travel distances, rugged terrain, seasonal inaccessibility, and limited healthcare infrastructure-factors that collectively affect diagnosis, treatment access, survivorship, and psychosocial outcomes. Despite growing interest in rural cancer disparities, few studies incorporate nuanced measures of rurality that account for these realities. This commentary outlines a research agenda that prioritizes extreme rurality in CCDR, highlighting promising metrics (RUCA, FAR, ARRS, ARIA+) and advocating for multilevel models that contextualize rurality alongside social determinants. Addressing these priorities will advance targeted interventions and promote equity in cancer care delivery.
Influence of life expectancy on shared decision-making for prostate cancer screening
Reed MM, Mao J, Davuluri M, Patel NA, Al Hussein Al Awamlh B and Kensler KH
The U.S. Preventive Services Task Force recommends that men aged 55-69 years undergo shared decision-making (SDM) regarding prostate cancer (PCa) screening, and routine screening is not recommended for older men or those with limited life expectancy. We evaluated the association between individual life expectancy and the receipt and content of SDM.
Rural women choose self-sampling over a pelvic exam for cervical cancer screening: a mixed-method study
Guetterman TC, Vinson A, Stack M, Alves ML, Haro E, Alman E, Butcher , Khoury CE, DeJonckheere M and Harper DM
Barriers to cervical cancer screening are significantly higher among US rural populations. To understand these barriers and explore potential remedies, we compare perceptions of screening exam techniques, pelvic exam vs. self-sampling, and how perceptions vary by participants' beliefs, physician characteristics, and known barriers among under-screened rural people in Michigan, United States.
Use of healthcare services and prescription medication prior to sarcoma diagnosis in children, adolescents, and young adults in 1997-2020: a population-based cohort study
Dybdal DTH, Davidsson ÓB, Søegaard SH, Petersen MM, Aggerholm-Pedersen N, Hjalgrim H, Rostgaard K and Hjalgrim LL
Sarcomas are among the leading causes of cancer death in children, adolescents, and young adults and survival has not been substantially improved for decades. Reducing the diagnostic interval could contribute meaningfully to increased survival at a low- cost. This study provided much-needed knowledge of the prediagnostic patient trajectories to direct future clinical efforts.
Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma
Benjamin WJ, Patil S, Mohebbi E, Latif S, Perera C, Bellile E, Wang K, Sartor MA, Taylor JMG, Wolf GT, Chinn SB and Rozek LS
To assess the impact of neighborhood-level disadvantage using the area disadvantage index (ADI) on survival outcomes in head and neck squamous cell carcinoma (HNSCC) patients.
Evaluating Now I Know mHealth intervention promoting HPV vaccine completion among young women attending federally supported clinics
Kim SK, Duncan R, Chittams J and Teitelman AM
This study evaluated the feasibility, acceptability, usability, and HPV vaccine completion rate of the Now I Know (NIK) mHealth intervention to promote HPV vaccine completion among minority and low-income young women.
The effect of cultural and linguistic diversity on the timeliness of prostate cancer treatment: a registry-based retrospective cohort study
Tamirat KS, Leach MJ, Papa N, Millar J and Ristevski E
To examine associations between culturally and linguistically diverse (CALD) status and definitive treatment delay among individuals diagnosed with intermediate- or high-risk prostate cancer (PCa) in Victoria, Australia.
Differences in prostate cancer treatment receipt and timeliness of treatment between African American/Black and White Iowans
Williams GJ and Zahnd WE
Non-Hispanic Black (NHB) men face higher prostate cancer (PCa) mortality rates compared to other racial/ethnic groups. Factors contributing to these disparities, particularly concerning healthcare system factors, remain uncertain. We investigate differences in treatment receipt and timeliness between NHB, non-Hispanic White (NHW) and Hispanic Iowans, examining variations across treatment facilities.
Circulating biomarkers of infection and endometrial cancer risk
Michels KA, Jin D, Jeske R, Lissowska J, Pepłońska B, Wentzensen N, Waterboer T and Trabert B
Incidence and mortality rates for endometrial cancer are rising. We need to better understand the etiology of this disease and identify new risk factors. We examined whether common genital infections are associated with endometrial cancer.
Correlates of patient-centered discussions on colorectal cancer screening: results from the health information national trends survey (HINTS)
Langford AT, Akpo MS, Buderer N and Xu J
In 2021, the U.S. Preventive Services Task Force lowered the recommended start age for colorectal cancer (CRC) screening to 45 years. In this study, we examined sociodemographic and health-related factors associated with U.S. adults being told about different CRC screening tests by health professionals.
A survey of cancer affiliate network hubs in the US: goals, composition, resources, and evaluation
Wahlen MM, Schroeder MC, Bojorquez PY, Birken SA, Semprini JT, Gorzelitz JS, Seaman AT, Sadri L, Broman K, Lizarraga IM and Charlton ME
Community hospitals play a critical role in cancer care delivery across the US but face challenges in providing needed services and specialized expertise. Cancer affiliate networks, i.e., formal/informal relationships between a large cancer center (hub) and community cancer centers (affiliates), can potentially improve quality in small hospitals where many Americans receive care. However, published descriptions of these networks are lacking. Thus, we aimed to identify and describe cancer networks across the US.
Fertility preservation in rare ovarian malignancies: a decade-spanning systematic review of menstrual and reproductive outcomes
Zerdeva E, Karampas G, Petrogiannis N, Athanasiadou CR, Diamanti A, Bolou A, Kokkinari A, Gourounti K and Sarantaki A
Fertility preservation is a growing priority in the management of young women with rare ovarian tumors, including malignant ovarian germ cell tumors (MOGCTs), sex cord-stromal tumors (SCSTs), and borderline ovarian tumors (BOTs). These malignancies often affect adolescents and women of reproductive age and are frequently treated with fertility-sparing surgery and platinum-based chemotherapy. Our objective is to systematically evaluate reproductive outcomes, menstrual function recovery, and fertility preservation strategies in female survivors of rare cancers such as MOGCTs, SCSTs, and BOTs.
Rural-urban disparities in colorectal cancer screening in United States: Blinder-Oaxaca decomposition analysis of BRFSS data
Owusu DN, Mensah EA, Mamudu S, Brooks B and Shoham D
Colorectal cancer (CRC) remains a leading cause of cancer mortality in the United States. While screening significantly reduces CRC incidence and mortality, disparities persist, particularly between rural and urban populations. This study assessed the extent and determinants of rural-urban disparities in CRC screening using nationally representative data from the Behavioral Risk Factor Surveillance System (BRFSS) between 2019 and 2023.
Association between legume consumption and risk of esophageal cancer among Chinese adults: a 17-year prospective cohort study
Huang F, Zhang X, Li J, Li X, Chen R, Wang S, Liu F and Wei W
Epidemiological studies have reported the influence of legume consumption on multiple cancers risk, but the association in esophageal cancer (EC) remains unclear. This study aimed to investigated the prospective associations between legume consumption and EC risk, especially among Chinese populations.
Association of distance to diagnosis and area-based social measures with stage at diagnosis among Iowans with HPV-related cancers
Janio E, Kahl AR, Kpozehouen D, Askelson N and Nash SH
Human papillomavirus (HPV) causes oral and anogenital cancers, the incidence of which is increasing. Late-stage diagnosis is associated with increased mortality. Neighborhood-level characteristics and distance to place of diagnosis may impact timely diagnosis. Being a largely rural state, Iowa presents a unique location to understand the association between distance, neighborhood characteristics, and stage at diagnosis.
Childhood and adolescent dietary patterns and incidence of benign breast disease
Garzia NA, Fest S, Cushing-Haugen K, Kensler TW, Chavarro JE, Tamimi RM and Harris HR
Childhood and adolescence may represent critical time windows for shaping future breast cancer risk. The association between early-life diet and breast cancer risk has been investigated, but few studies have examined the relation between adolescent diet and benign breast disease (BBD), an established breast cancer risk factor.
Alcohol and tobacco use among sexual and gender minority cancer survivors in relation to urbanicity/rurality
Robertson T, Fisher JL, Patterson JG, Scout NFN and Arthur EK
Understanding how place of residence affects cancer-related health risks is paramount to addressing health disparities in sexual and gender minority (SGM) cancer survivors. This study examined the associations between urbanicity and other social drivers of health on current tobacco and alcohol use in SGM cancer survivors.
Patterns of care and treatment delays among patients with early-stage breast cancer: long term impact of the COVID-19 (C19) pandemic
Jackson I, Sullivan M, Lei X, Giordano SH and Chavez-MacGregor M
To assess the long-term impact of the COVID-19 (C19) pandemic, we examined treatment patterns and delays in early-stage breast cancer (BC).