The potential role of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of coronavirus disease 2019 (COVID-19) is controversial, with concerns mainly about the part RAAS peptides play in the prediction of progression to more severe disease. Given the importance of COVID-19 prognostication at early disease stages, we established and validated a multivariable risk stratification tool for COVID-19 associated lung involvement by utilizing a combination of RAAS peptides.

Parrot fever, caused by Chlamydia psittaci, is a zoonotic disease typically treated with tetracyclines. Omadacycline, a novel aminomethyl tetracycline, has limited reports on its efficacy in severe Chlamydia psittaci pneumonia in the literature.

Most COVID-19 cases are mild, but some require hospitalization due to pneumonia, with symptoms like hypoxia and dyspnea. This has led to speculation about erythrocyte involvement in the infection. This study aimed to examine the differences in the presence of dysmorphic erythrocytes in COVID-19 patients upon admission compared to healthy subjects, as well as to assess these differences in relation to the severity of the clinical presentation of COVID-19.

The objective of this study was to characterize the occurrence of urosepsis in oncology patients and to explore the potential factors influencing its development and outcomes. Urosepsis is a serious systemic infection originating from a urinary tract infection. Its management is particularly challenging in immunocompromised oncology patients.

The coronavirus disease 2019 (COVID-19) pandemic has significantly accelerated the development of diagnostic techniques. Real‑time quantitative polymerase chain reaction (RT‑qPCR) was the method of choice for diagnosis and was considered as the gold standard. However, limited specificity of RT-PCR was noticed during the pandemic. This research aimed to develop a combined highly specific immune-based and highly sensitive molecular-based diagnostic technique.

Livestock is vital to Angola's economy, with cattle farming being especially important in Bié Province. Productivity is hampered by tick (Ixodida: Ixodidae) infestation, causing damage and potential transmission of pathogens. Despite known tick diversity in Angola, recent data for Bié Province are lacking.

Non-tuberculous mycobacteria (NTM) are a diverse group of environmental microorganisms, most non-pathogenic. Most people come into contact with NTM during their lives. Still, the infection occurs in people with previous lung comorbidities, weakened immune systems, and the elderly. This study aims to analyze the clinical characteristics of patients with NTM.

The hospital environment is an important source of nosocomial infections. Surfaces in the hospital facilities may be considered as microbial reservoirs that can cause patient contamination. This study aimed to evaluate the microbiological quality of surfaces and equipment in the Mohammed V Hospital, located in Al-Hoceima, Morocco.

Patients with perianal necrotizing fasciitis (PNF) frequently require admission to the intensive care unit (ICU). The study aimed to develop a novel scoring system to predict ICU admission in PNF patients.

With the large-scale use of antibiotics, the detection rate and mortality of carbapenem resistant Escherichia coli (CR-EC) have gradually increased. This study investigated the molecular characteristics and prevalence of CR-EC in order to supplement the isolated data of CR-EC in Hangzhou, China.

Severe viral and bacterial pneumonia are among the most common causes of death worldwide. This study investigated the effects and mechanisms of latent transforming growth factor beta binding protein 1 (LTBP1)'s on methicillin-sensitive Staphylococcus aureus (MSSA)-induced severe pneumonia following cytomegalovirus (CMV) reactivation.

This study aimed to assess tetanus seropositivity levels among adult patients admitted to a tertiary care hospital following rabies risk exposure, and to explore potential factors influencing their immunological status.

Hepatitis C virus (HCV) genotype 1 is a significant cause of hepatocellular carcinoma (HCC) in Vietnam. Direct-acting antivirals (DAAs) are effective in achieving sustained virologic response (SVR), potentially reducing HCC incidence. This study evaluated how DAA regimens affect HCC incidence in Vietnamese patients with chronic liver disease related to HCV genotype 1.

Cystic echinococcosis is a parasitic disease recognized as a global public health problem in countries engaged in agriculture and animal husbandry. In natural life cycle, ungulates are intermediate hosts: canids are definitive hosts. It could be accidentally transmitted to humans by the fecal-oral route and migrate to the liver and other visceral organs to form cystic echinococcosis. It spreads hematogenously, lymphatically, and locally. The majority of initially asymptomatic patients develop liver and lung involvement. Involvement of other organs is rare. Cystic echinococcosis is a disease diagnosed by radiologic imaging and confirmed by histopathology, serologic, and molecular tests that can be used for diagnosis and follow-up primary and secondary infections. In this case report, the involvement of multiple and rare organs of cystic echinococcosis is presented.

Phage therapy is a promising alternative for combating multidrug-resistant bacteria, including Acinetobacter baumannii (AB). However, the development of phage-resistant variants after treatment, particularly when using phage cocktails, poses a significant challenge. This resistance can hinder the effectiveness of future phage-based treatments against pathogenic AB.

Majority of patients admitted to intensive care units (ICUs) succumb to sepsis and its complications. However, currently available predictors fail to reliably gauge the severity of organ damage. There is a pressing need to identify biomarkers that can accurately forecast outcomes. Interleukin-6 (IL-6) has emerged as a potential biomarker, with some studies suggesting its utility as an early predictor of multi-organ failure in sepsis. This study evaluated the role of IL-6 in predicting mortality in an Indian ICU setting.

Drug-resistant Acinetobacter baumannii poses a global health crisis, especially in Asia. It has a propensity to become clonally endemic in healthcare settings. However, its clonal distribution in a broad geographic area is unclear.

Serum cryptococcal antigen (CrAg) screening is crucial for early diagnosis of cryptococcal meningitis. This study presents the results of CrAg screening among people living with HIV (PLWH) followed in our clinic over the past six years.

Acute gastroenteritis (AGE) remains a major public health concern for the pediatric population. Diarrheal surveillance in Venezuela following the implementation of the rotavirus vaccines has been discontinuous, resulting in a lack of knowledge of the true epidemiological burden. This study investigated retrospectively the occurrence of enteropathogenic virus infections and potential changes in the etiological pattern of diarrheal disease in Venezuelan children during the post-vaccination period.

Tuberculous empyema, a severe complication of pulmonary tuberculosis, often requires surgical intervention in stage III to remove fibrotic tissue and restore lung function.

African Swine Fever (ASF) poses a significant threat to swine populations and the global pork industry. Effective surveillance is critical for early detection and control of the disease. However, active surveillance programs may face challenges in sensitivity, particularly in regions like Serbia, where ASF is an emerging concern.